2-(Methylthio)benzimidazole → 1-{[2-(methylthio)-1H-benzimidazol-1-yl]methyl}-4-propylpyrrolidin-2-one

HRID 1295817

반응식

HRID 1295817 반응식
C(N(CC)C(=O)O[CH2:6][N:7]1[CH2:11][CH:10]([CH2:12][CH2:13][CH3:14])[CH2:9][C:8]1=[O:15])C.[CH3:19][S:20][C:21]1[NH:22][C:23]2[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=2[N:25]=1>C(#N)C>[CH3:19][S:20][C:21]1[N:22]([CH2:6][N:7]2[CH2:11][CH:10]([CH2:12][CH2:13][CH3:14])[CH2:9][C:8]2=[O:15])[C:23]2[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=2[N:25]=1

참가 물질

4

반응물 2

HCID 235392-(Methylthio)benzimidazoleHCID 11448237(2-Oxo-4-propylpyrrolidin-1-yl)methyl diethylcarbamate

생성물 1

HCID 111508421-{[2-(methylthio)-1H-benzimidazol-1-yl]methyl}-4-propylpyrrolidin-2-one수율 40.3%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of (2-oxo-4-propylpyrrolidin-1-yl)methyl diethylcarbamate a26 (1 eq, 3.18 mmol, 0.5 g) and 2-(methylthio)-benzimidazole (1.25 eq, 3.90 mmol, 0.64 g) in acetonitrile (4 ml) was heated under reflux for 42 h. The solvent was evaporated under reduce pressure and purification by preparative chromatography on reverse phase afforded 390 mg of 1-{[2-(methylthio)-1H-benzimidazol-1-yl]methyl}-4-propylpyrrolidin-2-one 90 (HPLC purity (U.V.): 85%; Yield: 40.3%).

후처리

  1. temperatureunder reflux for 42 h
  2. customThe solvent was evaporated
  3. custompressure and purification by preparative chromatography on reverse phase

출처 및 근거

ORD 기록
ord-ec4a7afc21ab4e00a3bd9ec8f4ba32d4
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07244747B2

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