Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Cyanophenylboronic acid → (3aR,6aR)-1-[4'-(2-methoxypyrimidin-5-yl)-1,1'-biphenyl-4-yl]-5-methyloctahydropyrrolo[3,4-b]pyrrole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Cyanophenylboronic acid | HCID 2734326 | — |
| 반응물 | 2-Methoxypyrimidine-5-boronic acid | HCID 2736778 | — |
| 반응물 | (3aR,6aR)-1-(4-Bromophenyl)-5-methyloctahydropyrrolo[3,4-b]pyrrole | HCID 44221503 | — |
| 생성물 | (3aR,6aR)-1-[4'-(2-methoxypyrimidin-5-yl)-1,1'-biphenyl-4-yl]-5-methyloctahydropyrrolo[3,4-b]pyrrole | HCID 24743816 | — |
반응 단계
The title compound was prepared according to the procedure described in Example 7D, substituting the product of Example 41A for the product of Example 7C and substituting 2-methoxy-pyrimidine-5-boronic acid for 4-cyanophenylboronic acid. 1H NMR (500 MHz, CDCl3) δ ppm 8.76 (s, 2H) 7.66 (d, J=8.54 Hz, 2H) 7.53 (dd, J=11.75, 8.70 Hz, 4H) 6.67 (d, J=8.85 Hz, 2H) 4.13-4.22 (m, 1H) 4.07 (s, 3H) 3.53-3.61 (m, 1H) 3.26-3.35 (m, 1H) 2.91-3.03 (m, 1H) 2.71-2.77 (m, 1H) 2.48-2.67 (m, 3H) 2.33 (s, 3H) 2.13-2.25 (m, 1H) 1.90-2.01(m, 1H). MS, (M+H)+=387.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728031B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-7ec783b5cf594ccfb60f56e13e3479b9 |
| 출처 메모 | uspto-grants-2010_06 |