(3-Chlorophenyl)boronic acid → 3'-Chloro-N-[5-(cis-3,5-dimethyl-1-piperazinyl)-2-(methyloxy)phenyl]-4-biphenylsulfonamide

참여 물질

반응 조건

반응 단계

To a mixture of 4-bromo-N-[5-(cis-3,5-dimethyl-1-piperazinyl)-2-(methyloxy)phenyl]benzenesulfonamide (E106) (75 mg, 0.17 mmol) and (3-chlorophenyl)boronic acid (56 mg, 0.36 mmol) in DME (3 ml) was added potassium tert-butoxide (180 mg, 1.60 mmol) and tetrakis(triphenylphosphine)palladium(0) (15 mg, 0.01 mmol) in water (1 ml) and the resulting mixture stirred in a microwave (set at high absorbance) at 100° C. for 30 minutes. The resulting mixture was then evaporated in vacuo and purified using an SCX cartridge eluting with methanol followed by ammonia (2M in methanol). The appropriate fractions were combined and evaporated in vacuo and the residue purified further by mass directed autoprep HPLC to afford the title compound (E111). MS (ES+) m/e 486/488 [M+H]+.

출처 및 근거