Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 130451생성일: 2026년 10월 24일
3-(Methoxymethyl)benzeneboronic acid → N-[5-(cis-3,5-Dimethyl-1-piperazinyl)-2-(methyloxy)phenyl]-3'-[(methyloxy)methyl]-4-biphenylsulfonamide
https://huagongshe.com/ko/reaction/130451
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-(Methoxymethyl)benzeneboronic acid | HCID 3825855 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 반응물 | 4-Bromo-N-[5-(cis-3,5-dimethyl-1-piperazinyl)-2-(methyloxy)phenyl]benzenesulfonamide | HCID 44452776 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | N-[5-(cis-3,5-Dimethyl-1-piperazinyl)-2-(methyloxy)phenyl]-3'-[(methyloxy)methyl]-4-biphenylsulfonamide | HCID 11562329 | — |
반응 단계
To a mixture of 4-bromo-N-[5-(cis-3,5-dimethyl-1-piperazinyl)-2-(methyloxy)phenyl]benzenesulfonamide (E106) (100 mg, 0.22 mmol) and {3-[(methyloxy)methyl]phenyl}boronic acid (75 mg, 0.45 mmol) in DME (3 ml) was added potassium tert-butoxide (220 mg, 1.96 mmol) and tetrakis(triphenylphosphine)palladium(0) (15 mg, 0.01 mmol) in water (1 ml) and the resulting mixture stirred in a microwave (set at high absorbance) at 100° C. for 30 minutes. The resulting mixture was then evaporated and purified by SCX followed by mass directed autoprep HPLC to afford the title compound (E117). MS (ES+) m/e 496 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07381728B2 |
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| 출처 데이터셋 | uspto-grants-2008_06 |
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| ORD ID | ord-d724e7a6f24948d8873265d878742dba |
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| 출처 메모 | uspto-grants-2008_06 |
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