Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3,5-Dimethylthioanisole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3,5-Dimethylbenzenethiol | HCID 117548 | — |
| 촉매 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 3,5-Dimethylthioanisole | HCID 2758662 | 88% |
반응 단계
10.0 g (0.072 mol) of 3,5-dimethylbenzenethiol, 9.95 g (0.072 mol) of potassium carbonate and 0.46 g (1.4 mmol) of tetrabutylammonium bromide are suspended in 20 ml of dimethylsulfoxide under argon. Iodomethane (10.2 g, 0.072 mol) is added dropwise, and the mixture is stirred 16 h at ambient temperature. After pouring the mixture into water, the product is extracted with ether, washed with water, dried over sodium sulfate and concentrated in vacuo. The crude product 9.6 g (0.063 mol; 88%) is obtained as a slightly yellow oil, and is used for the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07381842B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-5d140823334b42bab843a470f385b15a |
| 출처 메모 | uspto-grants-2008_06 |