Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → (S)-10-[3-(2-Methoxy-ethyl)-piperazin-1-yl]-2-isopropyl-4H-3-thia-4,9-diaza-benzo[f]azulene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | (S)-2-(2-Methoxyethyl)piperazine | HCID 55287560 | — |
| 반응물 | 2-isopropyl-4H-3-thia-4,9-diaza-benzo[f]azulene-10-ylamine hydrochloride | HCID 136384346 | — |
| 용매 | Dimethylsulfoxide toluene | HCID 22340214 | — |
| 생성물 | (S)-10-[3-(2-Methoxy-ethyl)-piperazin-1-yl]-2-isopropyl-4H-3-thia-4,9-diaza-benzo[f]azulene | HCID 136090342 | — |
반응 단계
Add 2-isopropyl-4H-3-thia-4,9-diaza-benzo[f]azulene-10-ylamine hydrochloride (0.32 g, 1.07 mmol) to a solution of (S)-2-(2-methoxy-ethyl)-piperazine (0.31 g, 2.15 mmol) in dimethyl sulfoxide: toluene (1:3, 4 mL). Add diisopropylethylamine (0.19 mL, 1.09 mmol), heat to 110° C. and stir. After an overnight period, cool to ambient temperature to give crude title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07384934B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-d1685ec605c04508b36d6f4b26a87993 |
| 출처 메모 | uspto-grants-2008_06 |