Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Ethyl alpha-(hydroxymethylene)-4-methoxyphenylacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Ethyl formate | HCID 8025 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Ethyl 4-methoxyphenylacetate | HCID 84174 | — |
| 생성물 | Ethyl alpha-(hydroxymethylene)-4-methoxyphenylacetate | HCID 67418551 | — |
반응 단계
8.9 ml of ethyl p-methoxyphenylacetate are dissolved in 80 ml of ethyl formate. 4.6 g of 50% NaH are added portionwise and then the mixture is stirred at ambient temperature for 12 hours. It is poured onto a 1N HCl solution and then extraction is carried out with AcOEt. Purification is carried out by chromatography on a silica column eluted with an AcOEt/heptane (05/95; v/v) mixture to produce 4.0 g of the expected compound in the liquid form.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07390818B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-ed1232b3a26c47d492e3e6672f4cbf4a |
| 출처 메모 | uspto-grants-2008_06 |