Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 3-(tert-butyldimethylsilyloxy)dihydrofuran-2(3H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 반응물 | alpha-Hydroxy-gamma-butyrolactone | HCID 545831 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-(tert-butyldimethylsilyloxy)dihydrofuran-2(3H)-one | HCID 5046241 | — |
반응 단계
9.0 g of imidazole and 15.9 g of t-butyldimethylsilyl chloride were added in order to a dimethylformamide (180 ml) solution of 9.0 g of 3-hydroxydihydrofuran-2-(3H)-one, and the reaction liquid was stirred for 1 hour at room temperature. The reaction liquid was diluted with ethyl acetate, washed with water, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=5/1) to obtain the entitled compound as a colorless oily substance.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728025B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-231380418bd64564bb18d212d111574c |
| 출처 메모 | uspto-grants-2010_06 |