Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Amino-3-Nitrophenol → 2-Nitro-4-(4-(3-pyridyl)pyrimidin-2-yloxy)phenylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Amino-3-Nitrophenol | HCID 3758882 | — |
| 반응물 | 2-Chloro-4-(pyridin-3-yl)pyrimidine | HCID 11805543 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-Nitro-4-(4-(3-pyridyl)pyrimidin-2-yloxy)phenylamine | HCID 22041340 | — |
반응 단계
A solution of 4-amino-3-nitro-phenol (1 eq) and 2-chloro-4-(3-pyridyl)pyrimidine (1 eq) in N,N-dimethylformamide was microwaved at 150° C. for 10 mins. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was concentrated and purified on silica gel to yield 2-nitro-4-(4-(3-pyridyl)pyrimidin-2-yloxy)phenylamine. MS: MH+=309.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728010B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-58cd6e076cab44f498affe8c636383fd |
| 출처 메모 | uspto-grants-2010_06 |