Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylamine → 4-chloro-N,N-dimethylpyridine-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylamine | HCID 674 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-chloropyridine-2-carbonyl Chloride | HCID 11095146 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-chloro-N,N-dimethylpyridine-2-carboxamide | HCID 4962252 | — |
반응 단계
A solution of 4-chloro-pyridine-2-carbonyl chloride (1 eq) in dichloromethane was cooled to 0° C., whereupon triethylamine (2 eq) was added followed by dimethylamine (2 eq, 2M solution in THF). The solution was allowed to warm to room temperature and let stir overnight. It was then washed with 1M NaOH. The separated organic layer is dried over MgSO4, filtered, and concentrated to yield the desired product. HPLC, 1.82 min; MS: MH+=185.6
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728010B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-af128e83c6f54f678c93c97cdc93799f |
| 출처 메모 | uspto-grants-2010_06 |