Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phthalimide → 2-[6-(Morpholin-4-yl)pyridin-3-yl]methylisoindol-1,3-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phthalimide | HCID 6809 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | [6-(Morpholin-4-yl)pyridin-3-yl]methanol | HCID 2776465 | — |
| 반응물 | Diisopropyl azodicarboxylate | HCID 5363146 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-[6-(Morpholin-4-yl)pyridin-3-yl]methylisoindol-1,3-dione | HCID 66961002 | 71.3% |
반응 단계
To a THF (200 mL) solution of (6-(morpholin-4-yl)pyridine-3-yl)methanol (CA 388088-73-1) (3.2 g), phthalimide (3.64 g) and triphenylphosphine (6.49 g), diisopropylazodicarboxylate (5.43 mL) was added at 0° C. for 5 minutes. The reaction solution was concentrated under reduced pressure after 12-hour stirring at room temperature. 3.8 g of the title compound was obtained by the residue was purified by silica gel chromatography (heptane-ethyl acetate system).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07880009B2 |
| 출처 데이터셋 | uspto-grants-2011_02 |
| ORD ID | ord-d4be582774c34f87a07e1490b5f1bb88 |
| 출처 메모 | uspto-grants-2011_02 |