Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Iodide → 2-Benzoyloxy-1,1-dimethoxy-ethane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 2-Chloro-1,1-dimethoxyethane | HCID 60986 | — |
| 반응물 | Potassium Benzoate | HCID 23661960 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-Benzoyloxy-1,1-dimethoxy-ethane | HCID 11608176 | 72.3% |
반응 단계
Chloroacetaldehyde dimethyl acetal (50.0 g), potassium benzoate (70.7 g), potassium iodide (6.66 g) and DMF (N,N-dimethylformamide) (250 mL) were placed in a three-neck flask, followed by refluxing. Twenty hours later, the reaction mixture was cooled to room temperature, and water (250 mL) and ethyl acetate (250 mL) were added thereto, followed by stirring. After filtration, the filtrate was extracted with ethyl acetate (500 mL). The organic layer was subjected to vacuum concentration and then to vacuum distillation at 132-135° C. and at 5 mmHg and thereby yielded the target compound (61.0 g) in a yield of 72%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728152B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-fc9b9235d9cf49359251140b795631d9 |
| 출처 메모 | uspto-grants-2010_06 |