참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Glutaric anhydride | HCID 7940 | — |
| 반응물 | 1-(3-Chloropropyl)piperazine | HCID 577606 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 5-[4-(3-Chloropropyl)piperazin-1-yl]-5-oxopentanoic acid | HCID 18521565 | 103.5% |
반응 단계
1.5 g of glutaric anhydride and then 2.13 g of N-(chloropropyl)piperazine in solution in 5 cm3 of dioxane and 1 cm3 of dichloromethane are added to 15 cm3 of dioxane in a round-bottomed flask kept under an argon atmosphere. After stirring for 2 hours at 20° C., the solvent is evaporated under reduced pressure (2.7 kPa) at 20° C., to give 3.75 g of 5-[4-(3-chloropropyl)piperazin-1-yl]-5-oxopentanoic acid in the form of a yellow oil which is used as it is.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07166594B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_01 |
|---|
| ORD ID | ord-96c1dc858ff74f3cb896a2f09e7f95e7 |
|---|
| 출처 메모 | uspto-grants-2007_01 |
|---|
