Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,3-Dihydroxybutanedioic Acid → Ritanserin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,3-Dihydroxybutanedioic Acid | HCID 875 | — |
| 반응물 | Ritanserin | HCID 5074 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | Ritanserin | HCID 5074 | 98% |
| 생성물 | 2,3-Dihydroxybutanedioate | HCID 3806114 | — |
반응 단계
A mixture of 4 parts of 6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one, 1.3 parts of (+)-[R-(R*,R*)]-2,3-dihydroxybutanedioic acid and 96 parts of 2-propanol was stirred and heated till all solid entered solution. The whole was cooled while stirring. The product was filtered off and dried, yielding 5.1 parts (98%) of (+)-6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one [R-(R*,R*)]-2,3-dihydroxybutanedioate(1:1).; mp. 198.7° C. (compound 147).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04581171 |
| 출처 데이터셋 | uspto-grants-1986_04 |
| ORD ID | ord-5e2f2c5ff7a74b2d848972eff23be1f6 |
| 출처 메모 | uspto-grants-1986_04 |