Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 6-Bromoindole-3-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 6-Bromoindole | HCID 676493 | — |
| 생성물 | 6-Bromoindole-3-carbaldehyde | HCID 2794830 | — |
반응 단계
POCl3 (980 mg, 6.4 mmol) was added dropwise to DMF (3 mL) cooled in an ice bath. The mixture was stirred at 0° C. for 30 min before a solution of 6-bromo-1H-indole (1.0 g, 5.1 mmol) in DMF (7 mL) was slowly added at 0° C. The mixture was stirred at room temperature for 3 h before being poured into water and neutralized with 1N NaOH. The crude product was collected by filtration and used in next step without further purification. LCMS (m/z): 224.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08906900B2 |
| 출처 데이터셋 | uspto-grants-2014_12 |
| ORD ID | ord-b11a318bb24540bbb61be046c7947240 |
| 출처 메모 | uspto-grants-2014_12 |