Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1415939생성일: 2026년 10월 23일
Dimethylformamide → 1-(3-amino-4,6-difluorophenyl)-7-[(3S)-3-aminopyrrolidin-1-yl]-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid triethylamine salt
https://huagongshe.com/ko/reaction/1415939
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-(3-Amino-4,6-difluorophenyl)-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid | HCID 11089970 | — |
| 반응물 | (3S)-(+)-3-Aminopyrrolidine Dihydrochloride | HCID 13500644 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Diisopropyl Ether | HCID 7914 | — |
| 생성물 | 1-(3-amino-4,6-difluorophenyl)-7-[(3S)-3-aminopyrrolidin-1-yl]-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid triethylamine salt | HCID 69960535 | 142% |
반응 단계
To 1,000 mg of N,N-dimethylformamide were added 220 mg of 1-(3-amino-4,6-difluorophenyl)-7-chloro-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid, 210 mg of (3S)-3-aminopyrrolidine dihydrochloride, and 400 mg of triethylamine. The solution was stirred at 90° C. for 1.5 hours. The reaction solution was allowed to cool down, combined with 10 ml of ethanol, heated at reflux for 5 minutes, and allowed to cool down. The precipitate was collected by filtration and washed with ethanol and then with diisopropyl ether to give 220 mg of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05910498 |
|---|
| 출처 데이터셋 | uspto-grants-1999_06 |
|---|
| ORD ID | ord-8325b659aecf44de9f6a0364c03a3721 |
|---|
| 출처 메모 | uspto-grants-1999_06 |
|---|
