Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → Ethyl cis(+/-)-2-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-methyl-1,3-thiazole-4-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 4-Thiazolecarboxylic acid, 2-bromo-5-methyl-, ethyl ester | HCID 13015591 | — |
| 반응물 | Benzyl cis(+/-)-[3-methoxypiperidin-4-yl]carbamate | HCID 86648490 | — |
| 생성물 | Ethyl cis(+/-)-2-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-methyl-1,3-thiazole-4-carboxylate | HCID 86648491 | 47.8% |
반응 단계
The same operation as in Example (38b) was performed using benzyl cis(±)-(3-methoxypiperidin-4-yl)-carbamate obtained in Example (40b) (0.2 g, 0.76 mmol), diisopropylethylamine (0.25 mL, 1.44 mmol) and ethyl 2-bromo-5-methyl-1,3-thiazole-4-carboxylate obtained in Example (40c) (0.2 g, 0.80 mmol), to obtain 157.6 mg of the title compound as a yellow oily substance (48%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08927588B2 |
| 출처 데이터셋 | uspto-grants-2015_01 |
| ORD ID | ord-dbe9e32be8cf4a188288f25971e43d2d |
| 출처 메모 | uspto-grants-2015_01 |