Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 6-(4-chloro-2-pyridinyl)-2-pyridin-2-yl-1H-pyrimidin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Pyridine-2-carboximidamide hydrochloride | HCID 12403615 | — |
| 반응물 | 3-(4-Chloropyrid-2-yl)-3-oxopropionic acid ethyl ester | HCID 53404617 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 6-(4-chloro-2-pyridinyl)-2-pyridin-2-yl-1H-pyrimidin-4-one | HCID 178515630 | — |
반응 단계
13.15 g (58 mmol) of 3-(4-chloropyrid-2-yl)-3-oxopropionic acid ethyl ester are dissolved in 400 ml of ethanol, and 9.10 g (58 mmol) of 2-amidinopyridine hydrochloride are added. After the addition of 14.44 ml of 4N sodium hydroxide solution, refluxing is carried out for 7 hours. The mixture is cooled and concentrated to a fifth of its original volume. The crude product is filtered off and recrystallised from methanol, yielding 6-(4-chloropyrid-2-yl)-2-pyrid-2-yl-pyrimidin-4-ol in the form of beige needles.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07612010B2 |
| 출처 데이터셋 | uspto-grants-2009_11 |
| ORD ID | ord-d9301c198d864dcfa44e24684afd95e0 |
| 출처 메모 | uspto-grants-2009_11 |