4-Benzyloxybenzylamine → (4-Benzyloxybenzyl)[6-methoxy-2-(4-methoxyphenyl)indan-4-yl]methylamine

HRID 1434438

반응식

HRID 1434438 반응식
FC(F)(F)S(O[C:7]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[C:12]2[C:8]=1[CH2:9][CH:10]([C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)[CH2:11]2)(=O)=O.C(OC1C=CC(CN)=CC=1)C1C=CC=CC=1.[CH2:44]([O:51][C:52]1[CH:78]=[CH:77][C:55]([CH2:56][NH:57][C:58]2C=C(OC)C=C3C=2CC(C2C=CC(OC)=CC=2)C3)=[CH:54][CH:53]=1)[C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1>>[CH2:44]([O:51][C:52]1[CH:53]=[CH:54][C:55]([CH2:56][NH:57][CH2:58][C:7]2[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[C:12]3[C:8]=2[CH2:9][CH:10]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[CH2:11]3)=[CH:77][CH:78]=1)[C:45]1[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=1

참가 물질

4

반응물 3

HCID 42928454-BenzyloxybenzylamineHCID 230872886-Methoxy-2-(4-methoxyphenyl)indan-4-yl trifluoromethanesulfonateHCID 66627646HCID 66627646, 화합물

생성물 1

HCID 66626750(4-Benzyloxybenzyl)[6-methoxy-2-(4-methoxyphenyl)indan-4-yl]methylamine

실험 절차

Synthesized from 6-methoxy-2-(4-methoxyphenyl)indan-4-yl trifluoromethanesulfonate and 4-benzyloxybenzylamine according to an analogous synthetic method to Example 116, (4-benzyloxybenzyl)[6-methoxy-2-(4-methoxyphenyl)indan-4-yl]amine (1.2 g) was used according to an analogous synthetic method to Preparation Example 18 to provide the title compound (1.0 g).

후처리

  1. customwas used according to an analogous synthetic method to Preparation Example 18

출처 및 근거

ORD 기록
ord-bdaefb2622ee477a80319fb0de2a010f
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612114B2

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