Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid → Acetic acid, (dimethoxyphosphinyl)hydroxy-, (4-nitrophenyl)methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | (4-Nitrophenyl)methyl oxoacetate | HCID 12544839 | — |
| 반응물 | Dimethylphosphite | HCID 21884954 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | Acetic acid, (dimethoxyphosphinyl)hydroxy-, (4-nitrophenyl)methyl ester | HCID 10064522 | — |
반응 단계
To a mixture of 4.32 g of p-nitrobenzyl glyoxalate and 2.0 ml of dimethylphosphite in 25 ml of benzene is added a catalytic amount of p-toluenesulfonic acid. The reaction is heated at reflux temperature for 1.5 hours. The formed water is removed using a Dean-Stark trap. After cooling, the solvent is removed in vacuo and the resulting crystals are slurried in ethyl acetate and collected to give 3.48 g of the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05602118 |
| 출처 데이터셋 | uspto-grants-1997_02 |
| ORD ID | ord-410c7e0886004c46b86f1c1c68aec268 |
| 출처 메모 | uspto-grants-1997_02 |