참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | 2-[1-(N-phenylmethoxycarbonylcarbamimidoyl)piperidin-4-yl]ethyl methanesulfonate | HCID 140379084 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | benzyl N-[4-(2-azidoethyl)piperidine-1-carboximidoyl]carbamate | HCID 140379074 | — |
반응 단계
In 100 ml of dimethylformamide was dissolved 4.4 g (0.0115 mol) of crude 1-benzyloxycarbonylamidino-4-mesyloxyethyl piperidine and 4.5 g (0.069 mol) of sodium azide was added. The mixture was heated at 100° C. for 2.5 h. It was then poured into water and extracted with ethyl acetate three times. The combined organic phase was washed with water, dried (Na2SO4) and evaporated. The residue was flash chromatographed on silica gel using ethyl acetate/heptane 1/1 as eluent. Yield: 3.0 g (79%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05602253 |
|---|
| 출처 데이터셋 | uspto-grants-1997_02 |
|---|
| ORD ID | ord-9d073a34210149f1b03a3983c17e268b |
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| 출처 메모 | uspto-grants-1997_02 |
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