Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methylpiperidine → 4-(2-Butynyloxy)-5-fluoro-6-(2-methylpiperidino)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methylpiperidine | HCID 7974 | — |
| 반응물 | 4-(2-Butynyloxy)-5-fluoro-6-chloropyrimidine | HCID 22599717 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-(2-Butynyloxy)-5-fluoro-6-(2-methylpiperidino)pyrimidine | HCID 59341115 | 71.1% |
반응 단계
Into 3 ml of ethanol was resolved 0.3 g of 4-(2-butynyloxy)-6-chloro-5-fluoropyrimidine, 0.45 g of 2-methylpyperidine was added therein, and the mixture was stirred for 5 hours under reflux condition. The reaction mixture was cooled to near room temperature and concentrated. The residue was subjected to silica gel column chromatography to obtain 0.28 g of 4-(2-butynyloxy)-5-fluoro-6-(2-methylpiperidino)pyrimidine (hereinafter, referred to as Compound (1)).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732448B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-128a683dc56a4a128028ba8b3f713edc |
| 출처 메모 | uspto-grants-2010_06 |