Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → 1-bromo-3-ethyl-5-nitroBenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | 2-Bromo-4-ethyl-6-nitroaniline | HCID 19973468 | — |
| 반응물 | Sodium Nitrite | HCID 23668193 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-bromo-3-ethyl-5-nitroBenzene | HCID 18929870 | — |
반응 단계
Dissolve 4-ethyl-2-nitro-6-bromoaniline (6.62g, 27mmol) in ethanol (40mL). Add, by dropwise addition, concentrated sulfuric acid (5mL) and heat at reflux, adding sodium nitrite (4.55g, mmol) in small portions over 25 minutes. Stir at room temperature for several hours, pour onto ice and extract into ethyl acetate. Wash with water (3×) and brine (3×). Dry (MgSO4) and evaporate the solvent in vacuo and purify by silica gel chromatography to give 3-bromo-5-ethylnitrobenzene.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05606063 |
| 출처 데이터셋 | uspto-grants-1997_02 |
| ORD ID | ord-3537f4ef0a8b4604818f49ac23273f0b |
| 출처 메모 | uspto-grants-1997_02 |