Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonate → 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonate | HCID 85570 | — |
| 반응물 | (-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid | HCID 2733226 | — |
| 반응물 | N-[1(S)-Ethoxycarbonyl-3-phenylpropyl]-L-alanine | HCID 5702571 | — |
| 생성물 | 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid | HCID 95489 | — |
반응 단계
The first step of Method-I consists of condensation of N-[1(S)-carboethoxy-3-phenylpropyl]-(S)-alanine (III) with the para-toluene sulfonate salt of the benzyl ester of (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid (IV) to give the benzyl ester of (S, S, S)-2-{2-{(1-ethoxycarbonyl)-3-phenylpropyl)amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid or quinapril benzyl ester which is isolated as the maleic acid salt (V).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07482361B2 |
| 출처 데이터셋 | uspto-grants-2009_01 |
| ORD ID | ord-ab98451813ec47e8a626bbdb71ae2dfa |
| 출처 메모 | uspto-grants-2009_01 |