Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Methoxytyramine → 4-{2-[4-(4-Ethoxy-phenyl)-pyrimidin-2-ylamino]-ethyl}-2-methoxy-phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Methoxytyramine | HCID 1669 | — |
| 반응물 | 4-(4-Ethoxy-phenyl)-2-chloro-pyrimidine | HCID 24901979 | — |
| 생성물 | 4-{2-[4-(4-Ethoxy-phenyl)-pyrimidin-2-ylamino]-ethyl}-2-methoxy-phenol | HCID 58603560 | — |
반응 단계
Intermediate 47 was coupled with 4-(2-Amino-ethyl)-2-methoxy-phenol following procedure F. LC-MS showed the product had the expected M+H+ of 366. 1H NMR (Varian 300 MHz, DMSO-d6, shifts relative to the solvent peak at 2.49 ppm) δ 8.0 (d, 1H), 7.1-7.0 (m, 4H) 6.8 (s, 1H), δ 6.7-6.6 (m, 3H), δ 4.0 (q, 2H), δ 3.7 (s, 3H), 3.5 (t, 2H), δ 2.7 (t, 2H), 1.3 (t, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732444B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-04e98fe9fae74dd793d532819d743de4 |
| 출처 메모 | uspto-grants-2010_06 |