Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrachlorophthalic anhydride → 4,4',5,5',6,7-hexachloro-3',6'-dihydroxy-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrachlorophthalic anhydride | HCID 8326 | — |
| 반응물 | 2-Chlororesorcinol | HCID 80331 | — |
| 용매 | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| 생성물 | 4,4',5,5',6,7-hexachloro-3',6'-dihydroxy-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one | HCID 87247028 | 91.8% |
반응 단계
Treatment of tetrachlorophthalic anhydride (5 g, 17.49 mmol) and 2-chlororesorcinol (7.58 g, 41.98 mmol) according to the procedure described in Example 1, Step 1, provided 9.3 g of the crude product. Suspension of 8 g of the crude 9.3 g in DMF:water (1:1), followed by filtration provided 8.65 g (16.05 mmol, 91.7% AUC yield) of 4,4′,5,5′,6,7-hexachloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one that was isolated as an orange solid. 1H NMR (300 MHz; DMSO d6) δ 11.09 (S, 2H), 7.03 (d, J=9 Hz, 2H), 6.81 (d, J=8.7 Hz, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09422260B2 |
| 출처 데이터셋 | uspto-grants-2016_08 |
| ORD ID | ord-fba0a47670f84b4eb95e46f3c9eeef56 |
| 출처 메모 | uspto-grants-2016_08 |