Pentafluorobenzene → 4,4,5,5-Tetramethyl-2-(pentafluorophenyl)-1,3,2-dioxaborolane

HRID 1490558

반응식

HRID 1490558 반응식
Fc1cc(F)c(F)c(F)c1F>C1=CCCC=CCC1.C1=CCCC=CCC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC1CCCC1.C[OH2+].C[OH2+].[Ir].[Ir].c1ccc(N2B(B3Nc4ccccc4N3c3ccccn3)Nc3ccccc32)nc1>CC1(C)OB(c2c(F)c(F)c(F)c(F)c2F)OC1(C)C

참가 물질

6

반응물 1

HCID 9696Pentafluorobenzene

생성물 1

HCID 230657134,4,5,5-Tetramethyl-2-(pentafluorophenyl)-1,3,2-dioxaborolane수율 87%

시약·촉매·용매 4

HCID 2733548Bis(pinacolato)diborane시약HCID 122380799HCID 122380799, 화합물시약HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium촉매HCID 138539Cyclopentyl methyl ether용매

반응 조건

온도
100 °C

실험 절차

The general procedure A was followed using 1,2,3,4,5-pentafluorobenzene (55.4 uL, 0.5 mmol) and B2pin2 (126.9 mg, 0.5 mmol, 1.0 eq.) as starting material. The resulting mixture was allowed to stir 16 hours at 100 oC. 5n was obtained as colorless oil (128.2 mg, 87%) after purification by silica gel flash chromatography (EtOAc/PE=1:10 v/v).

출처 및 근거

ORD 기록
ord-54534f29ec2f4a67ac86529f28d9ea02
출처 데이터셋
Borylation dataset from Roche

연결된 노트

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