Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Dimethylamino)ethanol → 4-benzyloxy-1-{4-[2-(dimethylamino)ethoxy]phenyl}-1H-pyridin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Dimethylamino)ethanol | HCID 7902 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| 반응물 | 4-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one | HCID 68431283 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-benzyloxy-1-{4-[2-(dimethylamino)ethoxy]phenyl}-1H-pyridin-2-one | HCID 11559625 | 66.6% |
반응 단계
4-Benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one (150 mg, 0.511 mmol), 2-(dimethylamino)ethanol (0.057 mL, 0.562 mmol), triphenylphosphine (269 mg, 1.02 mmols) and diethyl azodicarboxylate (0.163 mL, 1.02 mmols) were stirred overnight in THF (4 mL). Concentrating the reaction liquid under reduced pressure, the resulting residue was purified on silica gel column chromatography (C-300, methanol: chloroform=1:20-1:10) to provide the title compound (124 mg, 60%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732456B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-03e023041a31460a9e95a92d281c2f32 |
| 출처 메모 | uspto-grants-2010_06 |