Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1516607생성일: 2026년 10월 24일
(2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanol → (2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanone
https://huagongshe.com/ko/reaction/1516607
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | (2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanol | HCID 57437677 | — |
| 촉매 | Manganese dioxide | HCID 14801 | — |
| 촉매 | HCID 178418406 | HCID 178418406 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanone | HCID 42631463 | — |
반응 단계
A mixture of (2,3-dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanol, (Intermediate 2) (2.3 g, 5.18 mmol) in CH2Cl2 (40 mL) was treated with manganese(IV) oxide, activated (commercially available from Aldrich): MnO2 (4.5 g, 52 mmol) at rt. The mixture was heated to 60° C. for 2 h. The mixture was then cooled to rt and filtered through celite and the solvent was removed under vacuum. The residue was purified by MPLC with 3 to 5% MeOH:CH2Cl2 to give (2,3-dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanone, (Intermediate 3) (2.2 g, 96%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08227499B2 |
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| 출처 데이터셋 | uspto-grants-2012_07 |
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| ORD ID | ord-caca0991eebb49049c8c382f779bf8ad |
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| 출처 메모 | uspto-grants-2012_07 |
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