참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Benzenamine, N-sulfinyl- | HCID 70739 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | Ethyl 2-(2,1,3-benzothiadiazol-5-yl)-4-(4-methoxyphenyl)-4-oxobutanoate | HCID 10926758 | — |
| 반응물 | Ethyl 2-(benzo[c][1,2,5]thiadiazol-5-yl)acetate | HCID 11127870 | — |
| 반응물 | 4-Cyclopentyloxy-3,5-dimethoxybenzaldehyde | HCID 11791603 | — |
| 반응물 | Ethyl 2-(3,4-diaminophenyl)acetate | HCID 12986345 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | HCID 11060875 | HCID 11060875 | — |
반응 단계
0.368 g of 4-cyclopentyloxy-3,5-dimethoxybenzaldehyde (“A”) and 0.52 g of ethyl 2-(2,1,3-benzothiadiazol-5-yl)-4-(4-methoxyphenyl)-4-oxobutanoate, m.p. 89° (obtainable by reaction of 5.5 g of ethyl 2-(2,1,3-benzothiadiazol-5-yl)acetate with 5.5 g of 2′-bromo-4-methoxyacetophenone and 4 g of potassium carbonate in 200 ml of acetone, 18 hours under reflux; ethyl 2-(2,1,3-benzothiadiazol-5-yl)acetate, m.p. 40-41° is obtained by reaction of 24.3 g of ethyl 3,4-diaminophenylacetate and 26.9 ml of thionylaniline in 80 ml of toluene, 4 hours under reflux) are added to a solution of 34 mg of sodium in 10 ml of ethanol and the mixture is heated under reflux for one hour. After addition of 1.4 ml of acetic acid, it is heated for a further 16 hours. The solvent is removed and the residue is worked up in the customary manner. 3-(2,1,3-Benzothiadiazol-5-yl)-4-(4-cyclopentyloxy-3,5-dimethoxy-benzyl)-5-hydroxy-5-(4-methoxyphenyl)-5H-furan-2-one is obtained, FAB 575.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06197800B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_03 |
|---|
| ORD ID | ord-17a359feab954b548052de3d5d6c93ea |
|---|
| 출처 메모 | uspto-grants-2001_03 |
|---|
