Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → benzyl 2-ethyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Benzyl chloroformate | HCID 10387 | — |
| 반응물 | 4-Methoxypyridine | HCID 69278 | — |
| 반응물 | HCID 178418443 | HCID 178418443 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | benzyl 2-ethyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate | HCID 53419195 | 89.9% |
반응 단계
To a solution of 4-methoxylpyridine 81 (4.41 g, 40.5 mmol) in toluene (200 mL) at −20° C. was added CbzCl (5.7 ml, 40.5 mmol) in toluene (200 mL) dropwise. After 15 min, ethylmagnesium bromide (23 mL, 2M in THF, 46 mmol) was added dropwise. After 1 hr, 10% aqueous HCl (100 mL) was added and the mixture stirred overnight. The mixture was separated and the organic layer was washed with sat. NaHCO3 and brine. It was dried and concentrated to afford 82 (9 g, 36.4 mmol, 89.9%) that was used directly in the next reaction.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732609B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-5516529a5feb4309858df49e05ee3ecc |
| 출처 메모 | uspto-grants-2010_06 |