Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → 2-Methyl-5-piperazin-1-yl-quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Tert-butyl 4-(2-methylquinolin-5-yl)piperazine-1-carboxylate | HCID 49851900 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Methyl-5-piperazin-1-yl-quinoline | HCID 49851901 | 96% |
반응 단계
1,1-dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate (D2) (1.1 g) in a 25% solution of trifluoroacetic acid in dichloromethane (10 mL) was stirred at r.t. under an inert atmosphere for 3 hours. The reaction mixture was concentrated under reduced pressure and desalted by means of a 20 g SCX cartridge affording the title compound in 96% yield (0.74 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732600B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-314d2ca9bbee4079b72a99444a2f8f77 |
| 출처 메모 | uspto-grants-2010_06 |