Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole → 2-Methyl-4-morpholino-5-fluoroindole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole | HCID 20258982 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-Methyl-4-morpholino-5-fluoroindole | HCID 20258992 | 72.4% |
반응 단계
Raney nickel (1.5 kg) was added to a solution of 214 g of 2-methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole in 3 l of ethanol and the mixture was refluxed for 3 hours. After completion of reaction the reaction mixture was cooled and Raney nickel was removed by filtration. Concentration of the filtrate gave 101 g of 2-methyl-4-morpholino-5-fluoroindole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04552879 |
| 출처 데이터셋 | uspto-grants-1985_11 |
| ORD ID | ord-caa16cf72c86432aa7a8903bd47b80c2 |
| 출처 메모 | uspto-grants-1985_11 |