Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzaldehyde → 1-Phenyl-3-(trimethylsilyl)-2-propyn-1-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | Trimethylsilylacetylene | HCID 66111 | — |
| 반응물 | Lithium bis(trimethylsilyl)amide | HCID 57426343 | — |
| 반응물 | HCID 178462446 | HCID 178462446 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-Phenyl-3-(trimethylsilyl)-2-propyn-1-ol | HCID 2760416 | — |
반응 단계
In step a, trimethylsilylacetylene (1) can first be reacted with a non-nucleophilic base, such as lithium hexamethyldisilazane, in a suitable aprotic solvent, such as tetrahydrofuran. The resulting lithium acetylide can then be reacted with the appropriate benzaldehyde compound of structure 2 to give the corresponding α-[(trimethylsilyl)-ethynyl]-benzenemethanol compound of structure 3.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05223518 |
| 출처 데이터셋 | uspto-grants-1993_06 |
| ORD ID | ord-f08f6bb0d6b64685a2e9a88036fa9754 |
| 출처 메모 | uspto-grants-1993_06 |