Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → HCID 53790301, 화합물

HRID 1590393

반응식

HRID 1590393 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([CH:8]=O)[CH:5]=[C:4]([Cl:10])[N:3]=1.[C:11]([CH:16]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:13][CH2:14][CH3:15])=[O:12]>ClCCl>[CH2:14]([O:13][C:11](=[O:12])[CH:16]=[CH:8][C:6]1[CH:7]=[C:2]([Cl:1])[N:3]=[C:4]([Cl:10])[CH:5]=1)[CH3:15]

참가 물질

4

반응물 2

HCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl esterHCID 27610242,6-Dichloropyridine-4-carbaldehyde

생성물 1

HCID 53790301HCID 53790301, 화합물수율 71.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The above aldehyde (1.2 g) was dissolved in dichloromethane (40 ml) and carboethoxymethylenetriphenylphosphorane (2.4 g) was added. After 18 hours at 25° the solution was concentrated in vacuo and the residue washed with hexane. Combined hexane washings were concentrated in vacuo to give ethyl-3-(2,6-dichloro-4-pyridyl)propenoate (1.2 g). NMR 1H : 7.50(2H,d), 2.28(2H,s), 6.52(2H,d), 4 29(2H,q), 1.32(3H,t).

후처리

  1. concentrationAfter 18 hours at 25° the solution was concentrated in vacuo
  2. washthe residue washed with hexane
  3. concentrationCombined hexane washings were concentrated in vacuo

출처 및 근거

ORD 기록
ord-71649b080b5447cf817ce0c7da1cbabd
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05202356

연결된 노트

불러오는 중…