Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Methyltryptamine hydrochloride → (+/-) 6-methyl-1-(1-(2-methoxynaphthalenyl)methyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Methyltryptamine hydrochloride | HCID 6917145 | — |
| 반응물 | 2-(2-Methoxynaphthalen-1-yl)acetaldehyde | HCID 54479553 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (+/-) 6-methyl-1-(1-(2-methoxynaphthalenyl)methyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole hydrochloride | HCID 18933134 | — |
반응 단계
To a stirred solution of 5-methyltryptamine hydrochloride (947 mg, 4.49 mmol.) in 20 mL of ethyl alcohol was added (2-methoxy-1-naphthyl)-acetaldehyde (1.0g, 4.99 mmol.). The solution was heated to reflux under nitrogen atmosphere for 40 hours. The reaction mixture was cooled to ambient temperature and the crude product isolated by filtration. Recrystallization from ethyl alcohol/2-butanone afforded product as a pale solid (705 mg). (mp. 245.3° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05736544 |
| 출처 데이터셋 | uspto-grants-1998_04 |
| ORD ID | ord-8ecf673b974d4301b6987eea7ed57e43 |
| 출처 메모 | uspto-grants-1998_04 |