Nimesulide sodium → Nimesulide

HRID 1599963

반응식

HRID 1599963 반응식
[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([N+:19]([O-:21])=[O:20])=[CH:10][C:11]=1[O:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)(=[O:4])=[O:3].[Na]>O>[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([N+:19]([O-:21])=[O:20])=[CH:10][C:11]=1[O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=[O:3])=[O:4]

참가 물질

3

반응물 1

HCID 9949422Nimesulide sodium

생성물 1

HCID 4495Nimesulide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

41 grams of nimesulide-sodium salt/βCD complex of 1:1 molar ratio are obtained as a yellow fine powder. The resultant nimesulide content is 20.0±0.2% measured by UV-spectrophotometry. Solubility properties are such that 100 mg of the complex can be dissolved in 6 ml of distilled water, resulting in a slightly opalescent solution with approximately 3.5 mg/ml nimesulide content. The solution has a pH value of 8.3±0.1.

출처 및 근거

ORD 기록
ord-87592eecbc6b49ae8a6ea060b10d42f4
출처 데이터셋
uspto-grants-1998_04
특허 번호
US05744165

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