Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Gadolinium → Gadobutrol (JAN/USAN/INN)
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Gadolinium | HCID 23982 | — |
| 반응물 | 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid trisodium salt | HCID 10862527 | — |
| 반응물 | 4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane | HCID 11094747 | — |
| 생성물 | Gadobutrol (JAN/USAN/INN) | HCID 15814656 | — |
반응 단계
The solution of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid sodium salt is directly reacted, as described in EP 448191, with 4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane to give the alkylated product, which can easily be complexed with gadolinium to give the final Gadobutrol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05977353 |
| 출처 데이터셋 | uspto-grants-1999_11 |
| ORD ID | ord-0988ac7a43f940019ae1c43b5ce8e647 |
| 출처 메모 | uspto-grants-1999_11 |