Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-Benzylpyrrolidin-3-yl methanesulfonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | N-benzyl-3-pyrrolidinol | HCID 69889 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 1-Benzylpyrrolidin-3-yl methanesulfonate | HCID 9899811 | — |
반응 단계
1-Benzyl-3-pyrrolidinol (1.1 g) in toluene (10 mL) at 0° C. was treated with triethylamine (1 mL) and methanesulfonyl chloride (0.53 mL), warmed to room temperature, washed with saturated aqueous sodium bicarbonate, water, and brine, dried over anhydrous sodium sulfate, and concentrated. 1H NMR (300 MHz, DMSO-d6) δ 7.31 (s, 5H), 5.21 (m, 1H), 3.65 (q, 2H), 2.82 (m, 2H), 2.5 (m, 2H), 2.36 (m, 2H), 2.1 (m, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737159B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-6aba10ad0d9e4fbfb043799c04450e0e |
| 출처 메모 | uspto-grants-2010_06 |