Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → 1-Benzylpyrrolidine-3-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 1-Benzylpyrrolidin-3-yl methanesulfonate | HCID 9899811 | — |
| 촉매 | Tetrabutylammonium Cyanide | HCID 165872 | — |
| 생성물 | 1-Benzylpyrrolidine-3-carbonitrile | HCID 4674579 | — |
반응 단계
A mixture of EXAMPLE 1G (1.5 g) and tetrabutlyammonium cyanide (3.15 gm) in acetonitrile (25 mL) was heated at 65° C. for 24 hours, poured into saturated aqueous sodium bicarbonate, and extracted with toluene. The extract was washed with distilled water, dried over anhydrous sodium sulfate, and concentrated. 1H NMR (300 MHz, CDCl3) δ 7.33 (s, 5H), 3.42 (m, 2H), 2.89 (m, 1H), 2.72 (m, 1H), 1.68 (b, 3H), 1.45 (m, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737159B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-0f73c1e849cc445a98e72179d7bd2338 |
| 출처 메모 | uspto-grants-2010_06 |