Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → tert-butyl N-(4-(chloromethyl)pyridin-2-yl)carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 2-(Boc-amino)-4-(hydroxymethyl)pyridine | HCID 23151001 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | tert-butyl N-(4-(chloromethyl)pyridin-2-yl)carbamate | HCID 21068467 | — |
반응 단계
tert-butyl(4-(hydroxymethyl)pyridin-2-yl)carbamate (600 mg, 2.679 mmol) was first treated with SOCl2 (3 ml) in CH2Cl2 (5 ml) at rt for 2 hrs. The solvent was removed to get a crude tert-butyl(4-(chloromethyl)pyridin-2-yl)carbamate. Then following General Procedure A, the title compound (667 mg, 68%) was prepared from 2-amino-4-chlorobenzenethiol (641 mg, 4.019 mmol), K2CO3 (1.8 g, 13.39 mmol) in DMF (20 ml).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08791161B2 |
| 출처 데이터셋 | uspto-grants-2014_07 |
| ORD ID | ord-1c19d27a4f7e40329187a3d81e899c27 |
| 출처 메모 | uspto-grants-2014_07 |