참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Naphthalenesulfonic acid | HCID 8420 | — |
| 반응물 | 2-Ethoxy-4,5-dihydro-1,3-oxazole | HCID 12730640 | — |
| 반응물 | 4-Fluoro-2,3-dihydro-1H-isoindole | HCID 14795867 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-Fluoro-2-(oxazolin-2-yl)isoindoline | HCID 19691978 | — |
반응 단계
A mixture of 4-fluoroisoindoline (400 mg), 2-ethoxy-2-oxazoline (400 mg), and β-naphthylsulfonic acid (30 mg) in 50 ml of toluene was stirred at 100° C. for 1 hour. The solvent as removed under reduced pressure, and the residue chromatographed on silica gel, eluting with 1-4% methanol in ethyl acetate, to give 4-fluoro-2-(oxazolin-2-yl)isoindoline, a compound of Formula (IB), m.p. 125°-129° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05726197 |
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| 출처 데이터셋 | uspto-grants-1998_03 |
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| ORD ID | ord-0aed4da618f94372b6ebcb5dce352131 |
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| 출처 메모 | uspto-grants-1998_03 |
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