참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | D-Phenylalanine | HCID 71567 | — |
| 반응물 | Sodium Nitrite | HCID 23668193 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | (R)-2-Bromo-3-phenylpropionic acid | HCID 11746403 | 43% |
반응 단계
Mix D-phenylalanine (186.4g, 1.128mol) and 49% hydrobromic acid (372.8g), cool to -5° C. and add, by dropwise addition, a solution of sodium nitrite (77.9g) in water (565mL) over a period of about 1 hour (vigorous gas evolution). Stir at -5° C. to 0° C. for 4 hours, extract into ethyl ether (3×1L), dry (MgSO4) and evaporate the solvent in vacuo. Purify by chromatography (5% acetic aci/95% methylene chloride) and distillation to give 3-phenyl-2(R)-bromopropionic acid (112g, 43%); bp 128°-135° C. @0.25 torr.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05430145 |
|---|
| 출처 데이터셋 | uspto-grants-1995_07 |
|---|
| ORD ID | ord-4ba112e7390d4c33b5fc407d5ff480b4 |
|---|
| 출처 메모 | uspto-grants-1995_07 |
|---|
