Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 4-Bromo-N-(1,3-dioxohexahydro-1H-isoindol-2(3H)-yl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 4-Bromobenzohydrazide | HCID 22219 | — |
| 생성물 | 4-Bromo-N-(1,3-dioxohexahydro-1H-isoindol-2(3H)-yl)benzamide | HCID 11428080 | 52% |
반응 단계
A mixture of cis-cyclohexanedicarboxylic anhydride (150 mg, 0.97 mmol) and 4-bromobenzoic hydrazide (220 mg, 1.02 mmol) in ethanol (10 mL) was heated under argon overnight. The solvent was removed via rotary evaporation. Purification by column chromatography on silica gel using 1/1 hexane/ethyl acetate as eluent provided 179 mg (52%) of the desired product as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737168B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-e941cb197f144f5d88753ad3b289e7fd |
| 출처 메모 | uspto-grants-2010_06 |