Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,6-Di-tert-butyl-4-(chloromethyl)phenol → (3,5-Di-tert-butyl-4-hydroxy-benzyl)-cyclohexyl-phosphinic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,6-Di-tert-butyl-4-(chloromethyl)phenol | HCID 12378601 | — |
| 반응물 | Dimethylcyclohexylphosphonite | HCID 21678155 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | (3,5-Di-tert-butyl-4-hydroxy-benzyl)-cyclohexyl-phosphinic acid methyl ester | HCID 57909097 | 51.2% |
반응 단계
A mixture of 10.47 grams (59 mmol) of dimethylcyclohexylphosphonite with 15.14 grams (59 mmol) of 3,5-di-tert-butyl-4-hydroxybenzyl chloride (CAS REG # 955-01-1) in 45 mL of toluene is refluxed for 2 hours and is cooled. The resultant precipitated crystals are collected by filtration, washed with toluene, then hexane and are dried under vacuum to obtain 11.5 grams (51% yield) of (3,5-di-tert-butyl-4-hydroxy-benzyl)-cyclohexyl-phosphinic acid methyl ester as a white solid mp 149-150° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08030435B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-e40d7e2e6f504d5cb0f0acf81a2d09f5 |
| 출처 메모 | uspto-grants-2011_10 |