Cesium fluoride → Methyl 2'-fluoro-5'-(methyloxy)-2-(tetrahydro-2H-pyran-2-yloxy)-1,1'-biphenyl-4-carboxylate

https://huagongshe.com/ko/reaction/1662340

참여 물질

역할	이름	HCID	투입량
반응물	Cesium fluoride	HCID 25953	—
반응물	2-Fluoro-5-methoxyphenylboronic acid	HCID 4157211	—
반응물	Methyl 4-bromo-3-(tetrahydropyran-2-yloxy)benzoate	HCID 16747841	—
촉매	HCID 178418397	HCID 178418397	—
용매	1,2-Dimethoxyethane	HCID 8071	—
생성물	Methyl 2'-fluoro-5'-(methyloxy)-2-(tetrahydro-2H-pyran-2-yloxy)-1,1'-biphenyl-4-carboxylate	HCID 57707262	71.8%

반응 조건

온도	90 °C

반응 단계

To a 2 dram vial charged with 2-fluoro-5-methoxyphenylboronic acid (available from Aldrich) (3.17 g, 18.7 mmol), tetrakis(triphenylphosphine)palladium (0) (0.719 g, 0.622 mmol), cesium fluoride (1.15 mL, 31.1 mmol), and 26.2 (1.96 g, 6.22 mmol), was added DME (20 mL). The reaction mixture was then heated at 90° C. overnight. The reaction was allowed to cool and then filtered and concentrated. The crude product was purified by combiflash (0 to 10% EtOAc/hexanes) yielding 26.3 (1.61 g, 71.8% yield).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08030354B2
출처 데이터셋	uspto-grants-2011_10
ORD ID	ord-72bfed00d73443308d9f04a6536efbb6
출처 메모	uspto-grants-2011_10