Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylmorpholine → N-(2-Amino-Pyrimidin-5-yl)-2-Chloro-5-(3-Trifluoromethyl-Benzoylamino)-Benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | Pyrimidine-2,5-diamine | HCID 229075 | — |
| 반응물 | 2-Chloro-5-(3-(trifluoromethyl)benzamido)benzoic acid | HCID 53401172 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(2-Amino-Pyrimidin-5-yl)-2-Chloro-5-(3-Trifluoromethyl-Benzoylamino)-Benzamide | HCID 24962185 | 73% |
반응 단계
A solution of intermediate 1 (Example 2) (380 mg, 1.11 mmol) in DCM was charged with CDMT (233 mg, 1.33 mmol), and NMM (0.3 mL, 2.73 mmol). After 1 hr of stirring, 2,5-diaminopyrimidine (121 mg, 1.10 mmol) was added and the solution was allowed to stir for 48 h. The mixture was concentrated and purified by HPLC to afford the title compound as a white solid (350 mg, 73%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08030487B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-22c9db19a4fe4ff899c5f9e817647a15 |
| 출처 메모 | uspto-grants-2011_10 |