Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2-Hydroxyethyl)piperazine → (5-Bromo-pyridin-2-yl)-(4-(2-hydroxy-ethyl)-piperazin-1-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| 반응물 | 5-Bromopyridine-2-carboxylic acid | HCID 608544 | — |
| 생성물 | (5-Bromo-pyridin-2-yl)-(4-(2-hydroxy-ethyl)-piperazin-1-yl)-methanone | HCID 58748747 | — |
반응 단계
The title compound was prepared from 5-bromo-pyridine-2-carboxylic acid (1.0 g, 5.0 mmol) and 2-piperazin-1-yl-ethanol (1.0 g, 7.7 mmol) according to Method A (Example 89). After the removal of solvent, the residue was triturated in hexane-Et2O (5:1 v/v) and the white solid filtered (1.0 g, 65%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08030487B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-569c74c6f5a64960b2cc5d88a1556b5b |
| 출처 메모 | uspto-grants-2011_10 |