Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1663494생성일: 2026년 10월 24일
3-Pyridinemethanol → 4-(3-Bromo-4-fluorophenyl)-3-{4-[(pyridin-3-ylmethyl)amino]-1,2,5-oxadiazol-3-yl}-1,2,4-oxadiazol-5(4H)-one trifluoroacetate
https://huagongshe.com/ko/reaction/1663494
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Pyridinemethanol | HCID 7510 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| 반응물 | N-[4-[4-(3-Bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl]-2,2,2-trifluoroacetamide | HCID 58755133 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-(3-Bromo-4-fluorophenyl)-3-{4-[(pyridin-3-ylmethyl)amino]-1,2,5-oxadiazol-3-yl}-1,2,4-oxadiazol-5(4H)-one trifluoroacetate | HCID 67435030 | 6.6% |
반응 단계
A solution of N-{4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}-2,2,2-trifluoroacetamide (50 mg, 0.11 mmol), nicotinyl alcohol (14 μL, 0.15 mmol), and triphenylphosphine (42 mg, 0.16 mmol) in tetrahydrofuran (0.35 mL) at 0° C. was treated with diisopropyl azodicarboxylate (34 μL, 0.17 mmol). The reaction mixture was stirred at 25° C. for 16 h and purified by preparative LCMS to give the desired product (4 mg, 6%). LCMS for C16H11BrFN6O3 (M+H)+: m/z=432.9, 434.9.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08034953B2 |
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| 출처 데이터셋 | uspto-grants-2011_10 |
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| ORD ID | ord-33b53191e04a4bc6900732f2fa32c34d |
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| 출처 메모 | uspto-grants-2011_10 |
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