Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → N-{5-[(2-{[(2,2-dimethylcyclopropyl)carbonyl]amino}imidazo[1,2-b]pyridazin-6-yl)oxy]-2-fluorophenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 2,2-Dimethylcyclopropane-1-carboxylic acid | HCID 260708 | — |
| 반응물 | N-{5-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]-2-fluorophenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide hydrochloride | HCID 57505567 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | N-{5-[(2-{[(2,2-dimethylcyclopropyl)carbonyl]amino}imidazo[1,2-b]pyridazin-6-yl)oxy]-2-fluorophenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide | HCID 57505605 | 16.1% |
반응 단계
Using 2,2-dimethylcyclopropanecarboxylic acid (82 mg, 0.72 mmol), tetrahydrofuran (3.0 mL), N,N-dimethylformamide (20 μL, 0.26 mmol), oxalyl chloride (63 μL, 0.72 mmol), N-{5-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]-2-fluorophenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide.hydrochloride (200 mg, 0.48 mmol) and N,N-dimethylacetamide (4.0 mL), and in the same manner as in Example 239, the title compound (37 mg, 16%) was obtained as a white powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08034812B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-3e063f8494ec4215a107020542a870a7 |
| 출처 메모 | uspto-grants-2011_10 |